I know this is a little off topic, but its close enough.
While I wouldn't try to compare the economy of EU4 to the level of depth and interactive ability of Vic2, I do have to say it offers an interesting way of encouraging the expansionary policies that were prevalent in this era. That being said you can definitely have some fun.
With only taking the core tuscan provinces and genoa, you can dominate the genoa trade node with only half a dozen provinces. Of course this requires that you constantly develop your provinces. I was able to fund a 30 regiment size army complete with cavalry and cannons by 1550. Of course building tall isn't a complete success since, the estates become a pain to deal with, and you're till treated like a joke, but it's a work in progress I guess.
Anyway, that was one of my play throughs, personally learning how the economics of this game work was a hands on experience. I tried reading all about how it worked but I never really got too good an explanation from anything.
If anyone has any questions I'd be glad to try and help in anyway, also if anyone is interested, post stories of your economic super powers