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This is a Steam Error code referring to corrupted or missing program files. Check whether your Anti-Virus program has not quarantined any required files and have steam run a verification of your local files.
 
Please try this:

- uninstall PA from Steam
- unsubscribe from all mods in this game's Steam Workshop

Delete the following folders if still present:

- Steam/SteamApps/common/PA
- C:/users/<UserName>/AppData/Local/Introversion/Prison Architect/
(keep any valued save games, of course)
To see the AppData folder you'll need to enable View Hidden Items in File Explorer.

Now install PA again and see how that goes please!
 
Please try this:

- uninstall PA from Steam
- unsubscribe from all mods in this game's Steam Workshop

Delete the following folders if still present:

- Steam/SteamApps/common/PA
- C:/users/<UserName>/AppData/Local/Introversion/Prison Architect/
(keep any valued save games, of course)
To see the AppData folder you'll need to enable View Hidden Items in File Explorer.

Now install PA again and see how that goes please!


I did everything you said. It still comes up with the same error.

I am so frustrated! What can I do?
 
Delete everything in your Steam folder EXCEPT steam.exe and the SteamApps folder

Then run steam.exe to rebuild all that.

Good luck!
 
I just want to mention I had the same error after the 1.04 update, and reinstalling etc didn't help. But I discovered the issue was with F-Secure, the Deepguard function was blocking the game from launching and the solution was to add the Prison Architect folder to the "ignore" list.

Didn't have the problem until the 1.04 update, so I'm not sure what started causing it.