So many different things that it could be. You could take a look through your save game file and see if anything is obviously wrong.
So you only have two saves of that game, the Auto save and one manual save that you made? In other words you started a new game and only saved it once at the end of your first session, then it crashed when you went to play it a second time?
So you only have two saves of that game, the Auto save and one manual save that you made? In other words you started a new game and only saved it once at the end of your first session, then it crashed when you went to play it a second time?