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You have already tried #2 but try all three things together,
Also is this SP or MP game?
Okay let's try some standard things.
1) Rename the AVI folder to AVI_back
2) Set the color depth to 16BIT
3) Turn off everything in the background like E-mail/ICQ/Messenger, Virus protection and everything in the system tray beside the clock.
 
Okay the saving the game part is what I meant.

Try the three things together and let me know.
 
Did that clear up the problem?