Hello! Since you're playing with mods the first step is to check if there is any issues with the mods that you're playing with. Please try adding "--disableModding" as a launch option (https://pdxint.at/LaunchOptionsCS). This removes access to PDX Mods entirely, and if the game and a new save works with this enabled then the issue lies in the mods you have installed, and if you're unable to disable your mods in-game you can always do so on the web version.