I think my first play through will be like this:
EU
?Commander - can't decide yet, probably spur of the moment decision
Random Mystery
First rocket and first resupply rocket to set up colony - bring food on resupply rocket to last the founder stage and a bit longer. End up with power and a dome with: diner, grocer, research lab, infirmary, housing, one small park. Probably build a nursery and school during founder stage.
First colonist crew: only youth and adult, no middle aged; 2 medical, 6 scientist, 4 no-specialty for service buildings; try to get as few flaws and as many sexy as possible
Then build more housing, a farm (or 2 hydroponics if no farm tech) and a bar. Plan on placement for second dome.
Second colonist crew: 6 botanist, 3 no-specialty for service buildings, 3 scientists to work night shift. Yes, I plan on focusing on science.
Then have fun