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I am afraid none of Owen's advice will work in this situation, although it may help to reduce future problems, and how do you know he does not have the latest version of Dx?

Sounds like your save has become corupted some how, Are you running any user mods, have you edited any of the files yourself?

Can you load one of the autosaves and continue from there?
 
Then indeed you want to rename the AVI folder and also very important make sure you are set to 16BIT color.