First check that you have not enabled Debug mode, as that changes the checksum.
If that doesn't help, Please do a full clean re-install:
- move any valued save games elsewhere
- "uninstall" in Steam-Vic3
- manually delete both the Steam/SteamApps/common/Vic3 AND Documents/Paradox Interactive/Vic3 folders
- re-install game in Steam, run a Steam Verify when done.
- start the game with no mods active and test
In particular make sure there are no files or folders left under either the Steam Vic3 or Documents Vic3 locations, before installing again.
**File Locations on Mac OS X**
The executable and DLC folder are in Users/USER/Library/Application Support/Steam/SteamApps/common/Victoria3/
To see it go to the Finder, hit command-shift-G (ie Go To) and type in ~/Library/ .
The user files (settings files, error logs, saved games, mods) are in /Users/USER/Documents/Paradox Interactive/Victoria3/ .