All the patches after 1.30.x are slower than it was, but your report that 1.33 is much slower that 1.32 is not at all the general experience!
You've attached a save - is that because only it is affected and other saves, or new test games, are not? Or does this affect the game regardless?
DXDIAG is a program you run from the Windows search box on the task bar. After running it will open a window and start collecting info with a progress bar in the lower-left corner. When it completes click the 'save all information' button and save it to a file then attach that file here.
Please attach here your Documents/Paradox Interactive/EU4/settings.txt and pdx_settings.txt .
From your Documents/Paradox Interactive/EU4/logs/ folder, attach here system.log , error.log .