Not only that, but colonists with the idiot trait can still cause accidents in out-of-dome buildings they work at that makes them malfunction, something that the scrubbers can't prevent or fix.
If it's that big of a problem, stick the Idiots somewhere they can't do any harm.
The scrubbers greatly reduce out-of-dome maintenance, but they won't reduce maintenance on structures in-dome, making machine parts almost useless (except for fixing messes made by stupid colonists) and increasing the glaring difference in the availability of electronics related to everything else (since most of the best buildings in-dome use electronics or polymers)
Super-long-game, you could minimize this. The science buildings should hopefully be paying for themselves with Martian Copyrights (or, if not, there's no point and you should get rid of them). Schools are nice but not mandatory. Universities are a bigger deal than schools, but you COULD do without them if you had to. That leaves the factories themselves, which if you're minimizing maintenance should be limited themselves.
Polymer is truly infinitely available, provided you have space for enough vaporators.
Actually, I expect the biggest problem (assuming you can negate out-of-dome maintenance with scrubbers, which I guess maybe you can't if they're bugged like you say) would be concrete. You can get a certain amount from wonders, but the rate is limited, so if your concrete maintenance goes too high, you'll run out eventually (unless you roll the Nano Refinement breakthrough). And lots of in-dome buildings require it, including both grocers and diners and all residences except Smart Houses, which require also-limited Electronics, and Arcologies, which are limited to one per dome). Maybe you could work something out by relying entirely on Arcologies for residences and having everyone eat unprepared food, but that sounds rather dubious.
Lastly, but they're a bit bugged so when you've constructed a large number some have a tendency to stop working until you toggle power for them.
And this, if everyone suffers from it, is probably the final nail in the coffin for going infinite without Nano Refinement.
All that said, I don't think resource depletion is as much of a problem for the endgame as the lack of any meaningful content other than just trying to go infinite for kicks. I'm already in that state (mystery resolved, all wonders built, etc) and wondering whether just getting bigger for the sake of it is worth it, and I still have resource deposits I haven't even started mining yet.