Here is a sample view of a map I am working on. It is 4096x2304. It spans from Vinland in the west to the Indus River in the east, and from Scandinavia in the north to Mogadishu, Somalia in the south. Due to the expanded area of the map, Europe is only slightly larger than the vanilla map. I still debate if I care to have Vinland at all, and just have south Greenland for Norse settlements since those were important ones, which would allow me to cut that little piece of South America out of the map too.
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You can (and probably should) hide that part behind Terra Incognita.
Same goes for most Atlantic islands like the Azores, Madeira (put "Atlantis" there on the map, I guess