Some thoughts about my last run.
I was playing with the default rules for minor diseases and epidemics frequency. Also harm events set on dangerous (default) and targeting anyone. The rest of rules were on default and have no other relevant mods installed apart from DA.
I observed a very high mortality rate overall in europe, at rather younger ages (pre 40-50), and also many vanished dynasties and very small families.
Checking the causes of death randomly, apart from the epidemics, there is a significant number of children and adults dying from being ‘sickly’ and ‘ill’ respectively, and other ‘natural’ causes (fatal apoplexies everywhere!!

). This is before the black death fires.
While I very, very much enjoy the riskier experience that DA brings, I feel that the current combined effects of epidemics, diseases, harm events and (maybe?) riskier health issues from the mod, make the world seem a bit ‘underpopulated’ right now. E.g. Many rulers are single surviving members of dynasties, there are very few children around, many extinct cadet branches with only one (dead) member, etc.
I actually don’t know if this has anything to do with the mod, but maybe it could be related to the part of the diseases being riskier.
Have you experienced something similar? If that’s the case, probably the idea of introducing new game rules to adjust some of the most impacting mechanics is the way to go.
I will try with different rules and check again, but I wanted to share it anyway if it helps.