Given that your choices affect them, I doubt it. If you don't use the warp too much, you won't get invaded. It's a choice you make. If you don't rely too much on AI, you won't have a robot rebellion happen. It's all about what choices you make. If you're xenophobic and refuse to cooperate with other races, AI will be more necessary to supplement your existing capabilities, and you might face a rebellion. If you go fully multicultural, and form a gigantic federation, you'll need to use the warp more in order to get around, and space will be more likely to tear. If you play carefully and don't use the more dangerous techs, you probably won't face disasters, but you'll more vulnerable to mundane threats.