If the US has chosen to pursue the potential of nuclear power then instead of a nuclear weapon, is it unreasonable that the development would have been completed by 1946?
Yes, it is unreasonable. The engineering behind making simple pile reactors for demonstrating criticality and for plutonium production is not at all the same as making industrial nuclear power plants with steam turbine-generators. It wasn't until 1953-54 that basic prototype reactors were used in the Navy's Nautilus submarine and the Army's SM-1 reactor at Fort Belvoir. And these were only about 10 MW in electrical capacity! The first commercial power plants in the early 1960's were only about 100 MWe - not exactly the power source "too cheap to meter" to warrant a 25% boost to a nation's industry. It wasn't until the 1970's that 1000 MWe baseload plants were being built. Even then, and now, it's questionable whether a 25% "boost" is realistic.
Why so long? Unlike simple pile reactors, power plants require extensive instrumentation and control systems, safety systems, fuel management processes, operator training, etc., etc., etc. It's an iterative process that takes years to acquire experience in design engineering, construction techniques, operating procedures, and everything else. That stuff is not acquired in a lab someplace with a small team of Manhatten Project geniuses. The theory is easy; it's the implementation that's hard.
My recommendation as a nuclear engineer: break up 8972 Industrial Nuclear Power Plants into smaller sequential projects.
First would be Prototype Nuclear Power Plants, taking 5-10 years to develop a test reactor with no industry boost. Next would be Small Industrial Nuclear Power Plants taking another 5-10 years to achieve and providing a 5-10% boost. Finally would be Large Industrial Nuclear Power Plants taking another 5-10 years to achieve and providing a 10-20% boost. That's just a swag.
There's many players who use the No Time Limit mod with C.O.R.E. and like to continue the game into post-WW2 conflict.
What, into the 1960's and 1970's? That's what we're talking about for Industrial Nuclear Power Plants. This stuff would not have been achievable in the 1940's, and not until the late 1950's at the earliest. As the title suggests, the game's current simulation of nuclear power is vastly overstated. It needs to be toned down considerably.