I can see several major issues with those paths. First, the change from food "upkeep" for pop into energy. I can see a MASSIVE deficit happening in energy, especially in large empire. Bankrupt and empire destroying scale of deficit. Could we have the hydroponic farm turned into energy producing building of the same tier when this happen ? Since they become obsolete anyway. Or turn the food into energy (I don't know, biofuel ?). Also, it will force us to open the sector into being able to rebuild building, which may lead to issues by itself.
With the biological path, if the time required to mod a pop is not changed, we are looking at years of society research by endgame to change every pop of a single species. So, most likely a century or so for everyone in your empire if you play several races. That would be ridiculous.
Then, will we have the option to mod a species several time ? Right now, if you use gene mod on a species, we can't gene mod it later on, even if we have access to more gene point. So if I modify a species earlier on, then unlock more gene stuff in the biological path, I'd be screwed.
Dyson spheres for energy, problem solved, just build one before ascending.
The time to mod pops has been changed and gets less and less as you ascend, wiz has confirmed this on twitter, so no need to worry about that.
Also, since when could we not gene mod a species more then once? Yes we can gene mod species later even in the current game, you gain trait points as you tech up , you didnt know that? In my current game I have genemodded my entire species twice. There was never a limitation there. The only limitation was trait points.
Well maybe there was, but its definitely not true in the current version.