I think the choice between the Italian and the Turkish cultures is valid gameplay-wise if not historically so. For example if you choose the eastern path you will obviously go after the Turkish minors, and than Syria. And if I go west (without Italian culture), why would I even want Italy, with their overlapping cores, wrong culture that slows my research, and most of the provinces aren't even very rich!
Of course the Byzantine state isn't initially very close to the Italians, but IMO 150 or so years of friendship with Genoa, and other meddling in italian affairs would bring them closer together, and make Byzantine court somewhat "italianazied" which I think is very interesting too.
Edit: maybe another choice along the way between italian culture and cores in Italy, or latin techgroup and no culture and cores ?
Of course the Byzantine state isn't initially very close to the Italians, but IMO 150 or so years of friendship with Genoa, and other meddling in italian affairs would bring them closer together, and make Byzantine court somewhat "italianazied" which I think is very interesting too.
Edit: maybe another choice along the way between italian culture and cores in Italy, or latin techgroup and no culture and cores ?